PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
نویسندگان
چکیده
Laboratories of 1Molecular Immunology and 2Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; 3Department of Pediatrics, Division of Hematology-Oncology, and 4Department of Dermatology, Duke University Medical Center, Durham, NC; and 5Department of Pediatrics, Division of Hematology-Oncology, University of North Carolina School of Medicine, Chapel Hill, NC
منابع مشابه
Dysplasia of Granulocytes in a Patient with HPV Disease, Recurrent Infections, and B Lymphopenia: A Novel Variant of WHIM Syndrome?
WHIM syndrome is a condition in which affected persons have chronic peripheral neutropenia, lymphopenia, abnormal susceptibility to human papilloma virus infection, and myelokathexis. Myelokathexis refers to the retention of mature neutrophils in the bone marrow (BM), which accounts for degenerative changes and hypersegmentation. Most patients present heterozygous autosomal dominant mutations o...
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